Feren

Ferric pyrophosphate 30 mg (Liposomal)

Description

Ferric pyrophosphate (Liposomal)is an iron replacement product. Free iron presents several side effects as it can catalyse free radical formation and lipid peroxidation as well as the presence of interactions of iron in plasma. The ferric ion is strongly complexed by pyrophosphate. 1 lt presents an increasing interest as this insoluble form can be milder in the gastrointestinal tract and present higher bioavailability.

Indication

Iron Deficiency Anaemia (IDA)

IDA in CKD

HDD-CKD

Post Cardiac Surgery Anaemia

Associated Conditions

Haemodialysis-dependent chronic kidney disease (HDD-CKD)

Pharmacodynamics

Iron supplementation typically results in increases in serum iron, transferrin-bound iron, and iron-stored in the form of ferritin in hepatocytes and macrophages. The available iron is usually used in bone marrow for the synthesis of hemoglobin.9

Mechanism of action

The usage of ferric pyrophosphate is based on the strong complex formation between these two species. Besides, the capacity of pyrophosphate to trigger iron removal from transferrin, enhance iron transfer from transferrin to ferritin and promote iron exchange between transferrin molecules. These properties make it a very suitable compound for parenteral administration, iron delivery into circulation and incorporation into haemoglobin.

Side Effects

Along with its needed effects, ferric pyrophosphate may cause some unwanted effects. Although not all of these side effects may occur vizBloating or swelling of the face, arms, hands, lower legs, or feet, blurred vision, dizziness, faintness, or light-headedness when getting up suddenly from a lying or sitting position , tingling of the hands or feet , unusual tiredness or weakness , unusual weight gain or loss etc.

Dosages

Once Daily

How Supplied

Feren tablets are supplied as an coated Alu-Alu Packaging containing 30 mg of Ferric pyrophosphate (Liposomal) and Vitamin C 50 mg, Elemental iron 30 mg folic acid 300 mcg Vitb12 0.75 mcg)

Storage

Store in a Cool, Dry & Dark place. Protect from Light & Moisture.