Ketoneph

KETONEPH contains all amino acids essential for uremic patients, five out of them are keto or hydroxyanalogue in the form of calcium salts. Therefore it allows reduction in the nitrogen supply and provides calcium. It is a medication for the treatment of chronic kidney disease patients on Conservative management therapy (CKD stage I, II, III). In combination with very low protein diet / low protein diet, it helps in delaying the progression of kidney disease in the Predialysis period.

KETONPEH Composition:

Each film coated tablet contains (approximately)

Calcium-3-methyl-2-oxo-valerate (α-ketoanalogue to isoleucine, calcium salt)67 mg

Calcium-4-methyl-2-oxo-valerate (α-ketoanalogue to leucine, calcium salt)101 mg

Calcium-2-oxo-3-phenylpropionate (α-ketoanalogue to phenylalanine, calcium salt)68 mg

Calcium-3-methyl-2-oxo-butyrate (α-ketoanalogue to valine, calcium salt)86 mg

Calcium-DL-2-hydroxy-4(methylthio) butyrate (α-hydroxyanalogue to methionine, calcium salt)59 mg

L-Lysine 75 mg

L-Threonine 53 mg

L-Tryptophan 23 mg

L-Histidine 38 mg

L-Tyrosine 30 mg)

Total nitrogen content / tablet 36 mg

Calcium / tablet 1.25 mmol = 0.05 g

Indication

Ketoneph is used as a dietary supplement in Chronic Kidney Disease patients. Ketoneph is indicated in the chronic kidney disease (CKD stage 1, 2 & 3) for conservative management along with low protein diet. KETONEPH is useful for Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of 40 g per day (for adults) and less; i.e. generally in patients with a glomerular filtration rate (GFR) below 25 ml/min.

Contra-indications

Hypercalcaemia, disturbed amino acid metabolism. In case of hereditary phenylketonurie it has to be taken into account that this product contains phenylalanine. should be monitored regularly. An adequate supply of calories should be ensured.

Precautions and Warnings

No experience has been made so far with the application in pregnancy and pediatrics. KETONEPH should be taken during meals to allow proper absorption and metabolism into the corresponding amino acids. The serum calcium level

Undesirable effects

Hypercalcaemia may develop. In this case, it is recommended to decrease vitamin D intake. If the hypercalcaemia persists, reduce the dosage of KETONEPH as well as any other source of calcium.

Storage

Keep out of reach of children.
Store below 300 C
Do Not Freeze.

Dosage and Administration

In general, unless prescribed otherwise, four to eight tablets are swallowed whole three times daily during meals. This dosage applies to adults (70 kg bodyweight) (1 tablet/5 kg body weight/day).

Packing

KETONEPH is available as tablets in a blister of 10 tablets and 10 such blisters in a box.