Ketovibe Double Strength Alpha Ketoanalogues & Essential Amino Acids Tablets

Description

Ketovibe is part of the conservative treatment of patients with Chronic Kidney Disease. Ketovibe contains amino acids, partly in form of their corresponding-ketoanalogues, essential for patients with Chronic Kidney Disease. In combination with a protein-restricted diet Ketovibe is an excellent tool to treat Chronic Kidney Disease in the pre-dialysis period with high pill burden. It offers double strength of Alpha Ketoanalogues ensures the intake of essential amino acids and prevents deleterious consequences of inadequate dietary protein intake by reducing pill burden hence increasing patient compliance and convenience.

Benefits

Reduction of uremic symptoms, which are largely due to an accumulation of degradation products of the protein metabolism. Preservation of the residual renal function and therefore slowing down the rate of progression of the chronic kidney disease and delaying the onset of dialysis.

Preservation of the nutritional status, despite the marked reduction of the daily protein intake.

Improvement of metabolic complications due to renal insufficiency (e.g. proteinuria, disturbances in calcium-phosphate, carbohydrate and lipid metabolism)

Indications

Prevention & therapy of damages due to CKD till GFR is 15 ml/min, i.e. stages II, III & IV of CKD

Mechanism of Action :

On absorption alpha ketoanalogue get converted to their respective amines by taking up the Nitrogen from non essential amino acids, thus reducing the nitrogenous waste load on the kidneys and fulfilling the nutritional requirement.

Contraindications :

Hypercalcaemia, disturbed amino acid metabolism. In case of hereditary phenylketonurie it has to be taken into account that this product contains phenylalanine.

Precautions and Warnings :

No experience has been made so far with the application in pregnancy and pediatrics. Ketovibe should be taken along with meals to allow proper absorption and metabolism into the corresponding amino acids. The serum calcium level should be monitored regularly. An adequate supply of calories should be ensured.

Drug Interactions :

Simultaneous administration of medicinal products that contain calcium (e.g. acetolyte) may trigger, or worsen, a pathological increase in the serum calcium level.

As the uraemic symptoms improve under therapy with Ketovibe tablets, the dose of aluminium hydroxide administered should be reduced, as appropriate. The patient should be monitored for reduced levels of serum phosphate.

Dosage Form :

Oral Tablet, Dosage and Administration, 1 Tablet/10 kg body weight/day along with meal, divided in 3 equal dosage

Storage :

Do not use Ketovibe after expiry date, Keep out of the reach of children, Do not store above 25°C, Protect from moisture.