Renopride

Prucalopride1mg/2mg Tablets

Description

Prucalopride is a dihydrobenzofurancarboxamide with gastrointestinal prokinetic activities. Prucalopride is a selective, high affinity serotonin (5-HT4) receptor agonist, which is likely to explain its prokinetic effects. Indication

For the treatment of chronic idiopathic constipation in adults in whom laxatives fail to Provide adequate relief.

Dosage and Administration

2 mg once daily with or without food, at any time of the day. Due to the specific mode of action of prucalopride (stimulation of propulsive motility), exceeding the daily dose of 2 mg is not expected to increase efficacy. If the intake of once daily prucalopride is not effective after 4 weeks of treatment, the patient should be re-examined and the benefit of continuing treatment reconsidered.

Contraindication

It is contraindicated in patients with hypersensitivity, renal impairment requiring dialysis and Intestinal perforation or obstruction due to structural or functional disorder of the gut wall, obstructive ileus, severe inflammatory conditions of the intestinal tract, such as Crohn's disease and ulcerative colitis and toxic megacolon/megarectum.

Warnings & Precautions

Caution should be exercised when prescribing Prucalopride to patients with severe hepatic impairment (Child-Pugh class C) due to limited data in patients with severe hepatic impairment.

Drug Interactions

Prucalopride interacts with erythromycin and ketoconazole.

Side Effects

Decreased appetite, headache, dizziness, tremors, palpitations, nausea, diarrhea, abdominal pain, vomiting, dyspepsia, flatulence, gastrointestinal sounds abnormal, rectal hemorrhage, pollakiuria, fatigue, pyrexia and malaise

How Supplied

Renopride Tablets are supplied as Prucalopride Succinate eq to prucalopride 1/2 mg Film coated tablet.

Storage :

Store in a Cool, Dry & Dark place, Protect from Light & Moisture.